Mitochondrial dynamics links PINCH-1 signaling to proline metabolic reprogramming and tumor growth

Proline metabolism is critical for cellular response to microenvironmental stress in living organisms across different kingdoms, ranging from bacteria, plants animals. In bacteria and plants, proline known accrue osmotic other stresses. higher such as human, plays important roles physiology well pathological processes including cancer. The importance of diseases lies the fact that products are intimately involved essential protein synthesis, energy production redox signaling. A surge synthesis fast proliferating cancer cells, example, results markedly increased demand proline. frequently unable meet cells. inadequacy or “proline vulnerability” may provide an opportunity therapeutic control progression. To this end, it understand signaling mechanism through which regulated. a recent study (Guo et al., Nat Commun 11(1):4913, doi: 10.1038/s41467-020-18753-6), we have identified PINCH-1, component cell-extracellular matrix (ECM) adhesions, regulator